Hard water
ChemicalSubstanceWater with elevated dissolved calcium and magnesium content. Disrupts skin barrier function through four mechanistically independent pathways.
3 entities in this category
3 entities found in ChemicalSubstance starting with H Clear filters
Water with elevated dissolved calcium and magnesium content. Disrupts skin barrier function through four mechanistically independent pathways.
An essential amino acid with a uniquely skin-specific metabolic pathway. Filaggrin is particularly rich in histidine, and its degradation converts histidine to trans-urocanic acid.
A glycosaminoglycan that forms the water-retaining ground substance of the dermis and maintains the mechanical environment fibroblasts need for collagen synthesis.