Photoageing
BiologicalProcessThe pattern of UV-driven extrinsic skin ageing, distinct from chronological ageing in its mechanisms, distribution, and clinical appearance. Characterised by collagen fragmentation, solar elastosis.
Biological Process
39 entities in this category
Explore the Science of Biological Processes
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Postprandial glucose response
BiologicalProcessThe acute glucose and insulin trajectory following a meal, its amplitude, timing, and descent, determining both the immediate neurological environment and glycation accumulation.
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Randle cycle
BiologicalProcessThe Randle Cycle describes the reciprocal competition between glucose and fatty acids as cellular fuel sources; when one is being oxidised, it suppresses the other.
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Rapid weight loss
BiologicalProcessRapid weight loss, typically defined as loss exceeding 1–1.5kg per week, or greater than 1% of body weight per week sustained over multiple weeks
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Skin ageing
BiologicalProcessSkin ageing is the gradual decline of dermal structure, epidermal renewal, and barrier function, driven by intrinsic ageing and accelerated by environmental stressors.
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Skin circadian clock
BiologicalProcessThe circadian rhythm of the skin barrier describes the 24-hour molecular programme by which skin cells time their protective, regenerative, and repair functions.
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Telogen
BiologicalProcessHair resting phase lasting 2-4 months; normally only 10-15% of follicles are in this pre-shedding state at any time.
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Tissue regeneration
BiologicalProcessRepair outcomes range from true regeneration to fibrosis, determined by TGFβ isoform balance, macrophage M1→M2 transition, and inflammageing-related suppression of progenitor cells.
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Transepidermal water loss
BiologicalProcessTransepidermal water loss (TEWL) is the passive diffusion of water vapour through the epidermis and stratum corneum to the skin surface, where it evaporates into the surrounding air.