Creative Touch Permanent Makeup and Aesthetics

The circulatory system comprises two integrated subsystems: the cardiovascular system – the heart, arteries, veins, capillaries, and blood – and the lymphatic system – the network of lymphatic vessels, nodes, and lymphoid organs that drain interstitial fluid and support immune function. Together they constitute the body’s primary transport infrastructure, delivering oxygen, nutrients, hormones, and immune cells to tissues and removing metabolic waste.

In the context of aesthetic and regenerative medicine, the circulatory system is relevant in two distinct ways. First, as a procedural source system: iPRF and PRP are derived from the patient’s own blood, drawn via venepuncture from the peripheral venous system before centrifugation concentrates the platelet and growth factor payload for reinjection. ^[1] The therapeutic target of these treatments is the integumentary system, but the circulatory system is the origin of the material used. Second, as a treatment outcome system: growth factors delivered into the dermis – particularly VEGF – stimulate angiogenesis, the formation of new capillary networks that improve vascular supply to treated tissue. This is a circulatory system change produced by an integumentary system intervention, and it is clinically meaningful for tissue health and treatment longevity. ^[2]

Components relevant to Creative Touch treatment context

Cardiovascular: Heart (central pump) Arteries, arterioles, capillaries, venules, veins (distribution network) * Blood – plasma, erythrocytes, leukocytes, thrombocytes (platelets)

Lymphatic: Lymphatic capillaries and collecting vessels Lymph nodes Spleen, thymus (lymphoid organs) Lymph (interstitial fluid returned to circulation)

Microcirculation (most relevant to skin treatment context): Dermal capillary networks supplying the papillary dermis Arterioles and venules of the reticular dermis * Lymphatic capillaries draining dermal interstitial fluid

Treatments at Creative Touch with circulatory system relationships

iPRF: blood drawn from peripheral venous system (antecubital vein, typically 9–10ml) via venepuncture, centrifuged at low speed to produce platelet and growth factor concentrate. ^[1] The circulatory system relationship is procedural (source) and angiogenic (outcome). VEGF within the iPRF preparation stimulates capillary neovascularisation in treated tissue, producing a lasting improvement in dermal vascular supply – a circulatory system change that supports the integumentary system outcomes. ^[2]

System relationship: CirculatorySystem (source + angiogenic outcome). Primary therapeutic target: IntegumentarySystem.

LED therapy (red light): red light at 630–660nm penetrates to the dermis and activates cytochrome c oxidase in fibroblast mitochondria, increasing ATP production. This heightened cellular energy production induces vasodilation in dermal arterioles and capillaries, measurably increasing blood flow velocity and capillary density in treated tissue. The circulatory system relationship here is a secondary outcome of a primary integumentary system treatment rather than a procedural source interaction.

System relationship: CirculatorySystem (secondary outcome – dermal microcirculation). Primary therapeutic target: IntegumentarySystem.

RF microneedling, microneedling, thulium laser: wound-healing cascades initiated by these treatments involve platelet degranulation and localised vascular response, but the circulatory system interaction is transient and part of the healing mechanism rather than a primary treatment target or a meaningful lasting circulatory change. Not classified as circulatory system treatments.

Associated Pathophysiology

Circulatory system factors relevant to skin quality at Creative Touch include: declining dermal microcirculation with age reducing nutrient and oxygen delivery to dermal fibroblasts and basal keratinocytes; compromised papillary dermis capillary density contributing to the impaired epidermal support described in the Papillary Dermis entity; and VEGF-driven angiogenesis as a mechanism through which iPRF produces tissue quality improvements beyond its direct fibroblast activation effects. The lymphatic component is relevant to post-treatment recovery – lymphatic drainage of the dermal interstitial space affects how quickly inflammatory mediators resolve following professional treatments, and compromised lymphatic function can prolong recovery and reduce treatment outcomes.