Natural moisturising factor
AnatomicalStructureA mixture of hygroscopic compounds within corneocytes that binds water inside the stratum corneum. Predominantly derived from filaggrin degradation.
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8 entities found starting with N Clear filters
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Neurogenic inflammation
MedicalConditionA feedback loop in which sensory neurons and immune cells amplify each other via neuropeptides and cytokines, driving vasodilation, itch, and escalating inflammatory sensitivity.
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Neuropeptide
ChemicalSubstanceNeuropeptides are small signalling peptides released from nerve terminals in the skin, acting as chemical messengers between the nervous system and cutaneous immune, vascular, and epithelial cells.
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Neuropeptide Y
ProteinA 36-amino acid neuropeptide functioning as the brain's fastest and most potent orexigenic signal, a sympathetic co-transmitter in the periphery, and a pro-regenerative modulator in skin.
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NF-kappa B
ProteinThe master transcription factor coordinating skin inflammation. NF-κB activation simultaneously suppresses barrier proteins and upregulates collagen-degrading MMPs.
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NHE1
ProteinThe energy-dependent transmembrane transporter that actively pumps protons (H⁺) out of keratinocytes into the stratum corneum extracellular space.
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Niacinamide
MolecularEntityWater‑soluble vitamin B3 that boosts ceramide synthesis, supports cellular NAD⁺, and reduces inflammation and glycation to strengthen barrier and dermal integrity.
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Nicotinamide adenine dinucleotide
MolecularEntityCoenzyme present in every skin cell that powers both cellular energy metabolism and a suite of signalling enzymes, including the sirtuins that regulate the skin's circadian repair clock.