Vascular endothelial growth factor
BioChemEntityThe primary angiogenic growth factor in skin, produced by keratinocytes, dermal fibroblasts, and dermal papilla cells and stored in platelet alpha granules.
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The primary angiogenic growth factor in skin, produced by keratinocytes, dermal fibroblasts, and dermal papilla cells and stored in platelet alpha granules.
The red-coloured portion of lips, uniquely vulnerable due to thin barrier, absent sebum production, and minimal melanin.
Fat‑soluble vitamin whose active form (ATRA) regulates thousands of genes via nuclear receptors to drive epidermal renewal, boost collagen, suppress MMPs, and balance sebum.
Water‑soluble vitamin whose cofactor roles in methylation and fatty‑acid metabolism make deficiency visible as acral hyperpigmentation, hair changes, and barrier fragility.
Water-soluble B vitamin whose cosmeceutically active derivative - niacinamide (nicotinamide) - is the primary form relevant to skin biology
Water‑soluble vitamin that stabilises collagen by supporting hydroxylation enzymes and suppresses UV‑driven ROS that trigger MMP‑1 collagen breakdown.
Fat‑soluble secosteroid whose active form (calcitriol) is made in the epidermis and, via VDR, regulates keratinocyte differentiation, antimicrobial peptides, barrier function, and innate immunity.
Fat‑soluble antioxidant concentrated at the skin surface, where it blocks UV‑driven lipid peroxidation and squalene oxidation; regenerated by vitamin C, making them a coupled antioxidant system.
Fat‑soluble vitamin whose K1 and K2 forms share a GGCX‑dependent mechanism. K1 supports coagulation for wound repair, while K2 prevents elastin calcification and dermal stiffening.
A TLR2‑activating bacterial lysate that boosts epidermal AMP and antioxidant genes and improves barrier function and S. aureus colonisation in atopic dermatitis.
GI side effect of tirzepatide showing dramatic variation by injection site, with thigh injection reducing incidence by more than half.