Decorin
ProteinDecorin is a small leucine-rich proteoglycan of the dermal extracellular matrix. Primary regulator of collagen fibril diameter, interfibrillar spacing and the mechanical architecture of the dermis.
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13 entities found starting with D Clear filters
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Deoxycholic acid
ChemicalSubstanceDeoxycholic acid is a bile acid that disrupts adipocyte membranes on injection, producing necrosis and permanent fat‑cell loss followed by inflammatory clearance.
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Dermal Papilla
AnatomicalStructureA compact cluster of specialised fibroblasts at the base of each hair follicle that directs the hair growth cycle through paracrine signalling.
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Dermatitis
MedicalConditionDermatitis is a broad term for inflammatory skin conditions characterised by barrier dysfunction, immune activation, and varying degrees of erythema, pruritus, scaling, and vesiculation.
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Dermis
AnatomicalStructureThe structural layer beneath the epidermis, containing fibroblasts, collagen, elastin, and the ground substance that together determine skin firmness, elasticity, and resilience.
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Desquamation
BiologicalProcessThe pH-regulated enzymatic programme that sheds corneocytes from the stratum corneum surface at a rate matched exactly to keratinocyte production from below.
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Dexpanthenol
ChemicalSubstanceProvitamin form of pantothenic acid (B5) that converts to pantothenic acid within skin cells, supporting keratinocyte proliferation, dermal fibroblast migration, and barrier function.
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Diacylglycerol
ChemicalSubstanceA lipid intermediate that accumulates when fatty‑acid entry is blocked, activating PKC to drive IRS‑1 serine phosphorylation and impair insulin signalling.
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Dietary fat
ChemicalSubstanceA macronutrient category encompassing saturated, monounsaturated, polyunsaturated, and essential fatty acids, serve distinct and non-interchangeable functions in skin biology.
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Dietary protein
ChemicalSubstanceThe dietary macronutrient that provides the amino acid supply from which the body builds and maintains all structural and functional proteins, including collagen, keratin, elastin.
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Dihomo-gamma-linolenic acid
MolecularEntityAn omega-6 fatty acid formed from GLA, and the immediate precursor to both anti-inflammatory prostaglandins and pro-inflammatory arachidonic acid.
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Dihydrotestosterone
MolecularEntityThe locally amplified form of testosterone, produced in skin tissue by 5-alpha reductase enzymes. Drives sebaceous gland activity and sebum production.
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Docosahexaenoic acid
ChemicalSubstanceActive omega-3 fatty acid form (DHA) used directly by the body, supporting anti-inflammatory processes and cell membrane health.